ohdsi-questions
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ohdsi-questions [2018/03/21 07:23] rohit |
ohdsi-questions [2018/04/15 12:38] rohit |
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| - | OHDSI-Questions | + | ====OHDSI-Questions==== |
| ===Question - 1=== | ===Question - 1=== | ||
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| -Outcome - All-cause mortality as the primary outcome and asthma-related mortality as a secondary outcome. | -Outcome - All-cause mortality as the primary outcome and asthma-related mortality as a secondary outcome. | ||
| -Risk Window - 1st day of treatment exposure to end of the study. | -Risk Window - 1st day of treatment exposure to end of the study. | ||
| + | |||
| ===Question - 8=== | ===Question - 8=== | ||
| + | (Not sure what C/D stand for, I’ve asked this on the forum and will update once get a reply). | ||
| + | To compare the risk of asthma exacerbations between patients with Chronic Obstructive Pulmonary Disease (COPD) C/D and inhaled corticosteroids withdrawal versus patients with COPD C/D who have never used ICS. | ||
| + | -Treatment Cohort - Patients with COPD and inhaled corticosteroids withdrawal. | ||
| + | -Comparator Cohort - Patients with COPS not exposed to inhaled corticosteroids. | ||
| + | -Outcome - Asthma Exacerbations. | ||
| + | -Risk Window - 1 day after last exposure start to 180 days after the exposure end. | ||
| + | |||
| + | |||
| + | ===Question - 9=== | ||
| To compare the risk of serious cardiovascular events (sudden cardiac death, acute myocardial infarction, and stroke) between the new users of triptans versus patients who used triptans for one year (short-term) and more than one year (long-term). | To compare the risk of serious cardiovascular events (sudden cardiac death, acute myocardial infarction, and stroke) between the new users of triptans versus patients who used triptans for one year (short-term) and more than one year (long-term). | ||
| -Treatment Cohort - New users treated with triptans. | -Treatment Cohort - New users treated with triptans. | ||
| -Comparator Cohort - Patients treated with triptans for one year (short-term) and patients treated with triptans for more than one year (long-term). | -Comparator Cohort - Patients treated with triptans for one year (short-term) and patients treated with triptans for more than one year (long-term). | ||
| -Outcome - Sudden cardiac death, acute myocardial infarction, and stroke after exposure. | -Outcome - Sudden cardiac death, acute myocardial infarction, and stroke after exposure. | ||
| - | -Risk Window - 1 day after treatment exposure starts to 0 days after treatment exposure ends. | + | -Risk Window - 1 day after treatment exposure starts to 0 days after treatment exposure ends. |
| + | |||
| + | ===Question - 10=== | ||
| + | To compare the risk of osteoporosis or fracture increase in postmenopausal hypothyroid patients using high strength levothyroxine versus patients using low strength levothyroxine. | ||
| + | -Treatment Cohort - On treatment postmenopausal (age >=50 years) patients with hypothyroidism exposed to high strength of levothyroxine (>=0.044 mg/day). | ||
| + | -Comparator Cohort - On treatment postmenopausal (age >=50 years) patients with hypothyroidism exposed to low strength of levothyroxine (< 0.044 mg/day). | ||
| + | -Outcome - Osteoporosis or Fracture. | ||
| + | -Risk Window: From the first day of treatment with high or low strength levothyroxine until the end of cohort study, end of follow-up or death. | ||
| + | |||
| + | ===Question - 11=== | ||
| + | To compare the risk of chronic kidney disease (CKD) among patients exposed to proton pump inhibitors versus patients not exposed to proton pump inhibitors. | ||
| + | -Treatment Cohort - Patients with chronic exposure to proton pump inhibitors, age >= 18 years heaving no evidence of chronic kidney disease (eGFR < 60ml/ | ||
| + | -Comparator Cohort - Patients of age >= 18 with no exposure to proton pump inhibitors. | ||
| + | -Outcome - Incidence of chronic kidney disease. | ||
| + | |||
| + | ===Question - 12=== | ||
| + | To compare the risk of Atherosclerotic Cardiovascular Disease (ACD) between patients with a diagnosis of hyperlipidemia (HLD) on statins and elevated triglycerides treated with fibrates versus patients with a diagnosis of HLD on statins and elevated triglycerides not treated with fibrates. | ||
| + | -Treatment Cohort - Patients with a diagnosis of HLD on statins and elevated triglycerides treated with fibrates. | ||
| + | -Comparator cohort - Patients with a diagnosis of HLD on statins and elevated triglycerides not treated with fibrates. | ||
| + | -Outcome - Occurrence of Atherosclerotic Cardiovascular disease after treatment. | ||
| + | -Risk Window - 1 day after exposure start to 0 days after exposure ends. | ||
| + | |||
| + | ===Question - 13=== | ||
| + | To compare the risk of Atherosclerotic Cardiovascular Disease (ACD) between patients with a diagnosis of hyperlipidemia (HLD) on statins with ideal cholesterol versus patients with a diagnosis of HLD on statins with elevated cholesterol. | ||
| + | -Treatment Cohort - Patients with the diagnosis of HLD treated with statins and have ideal cholesterol level. | ||
| + | -Comparator Cohort - Patients with the diagnosis of HLD treated with statins and have elevated cholesterol level. | ||
| + | -Outcome - Risk of ACD. | ||
| + | -Risk Window - 30 days after exposure to statins to 0 days after exposure. | ||
| + | |||
| + | ===Question - 14=== | ||
| + | To compare the risk of developing malignancy in patients with moderate to severe rheumatoid arthritis treated with tofacitinib and tumor necrosis factor inhibitors (TNFi). | ||
| + | -Treatment Cohort - Patients with moderate to severe rheumatoid arthritis treated with tofacitinib. | ||
| + | -Comparator Cohort - Patients with moderate to severe rheumatoid arthritis treated with TNFi. | ||
| + | -Outcome - Any type of malignancy. | ||
| + | |||
| + | |||
| More discussion on these question can be seen here at [[http:// | More discussion on these question can be seen here at [[http:// | ||
ohdsi-questions.txt · Last modified: 2018/06/04 20:14 by nigam
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